AM1 study of structure-activity relationships in bicyclic aza-β-lactams |
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| Authors: | A Nangia P S Chandrakala M V Balaramakrishna and T V A Latha |
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| Institution: | a School of Chemistry, University of Hyderabad Hyderabad 500 046 India |
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| Abstract: | AM1 calculations on bicyclic aza-β-lactams 4 (1,3-diazetidin-2-ones) are carried out to investigate the effect of ring size (five versus six), position of olefin (Δ2 versus Δ3), and electronegative atom (oxygen) in the tethered non-β-lactam ring on the structure of diazetidinone. The results are discussed in terms of structural trends related to β-lactamase and transpeptidase inactivation capability. The biological activity of novel aza-β-lactams 4 is comparable to that of β-lactams3 . |
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