Recyclable Merrifield resin-supported thiourea organocatalysts derived from l-proline for direct asymmetric aldol reaction |
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| Authors: | Jia Li Gengxu YangYanyan Qin Xinran YangYuanchen Cui |
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| Affiliation: | a Key Laboratory of Ministry of Education for Special Functional Materials, Henan University, Kaifeng 475004, China
b School of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China |
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| Abstract: | Four Merrifield resin-supported thiourea organocatalysts derived from l-proline were synthesized and found to be efficient catalysts for the direct asymmetric aldol reaction between ketone and aromatic aldehydes. The catalysts exhibited high catalytic activity, diastereoselectivity and excellent enantioselectivity at room temperature with a low loading (only 2 mol %). They also retained unchanged enantioselectivities even after being reused for at least four cycles. |
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