Metallkomplexe mit biologisch wichtigen Liganden. CLXV N,O‐Chelat‐Komplexe von α‐Aminosäureanionen mit cyclopalladiertem N,N‐Dimethylferrocencarbothiamid

Metal Complexes of Biologically Important Ligands. CLXV N,O‐Chelate Complexes of α‐Amino Acid Anions with Cyclopalladated N,N‐Dimethylferrocenecarbothioamide A short literature review on the reactions of various chlorobridged complexes with α‐aminoacidates, α‐amino acid esters, peptide ester or derivatives of amino acids is given. The chloro bridged o‐palladated N,N‐dimethylferrocenecarbothioamide (fct)Pd(μ‐Cl)₂Pd(fct)] reacts with the anions of glycine, L‐alanine, L‐proline, L‐valine, L‐phenylalanine, L‐leucine, L‐isoleucine to give the N,O‐chelates (fct)Pd(N,O‐α‐aminocarboxylate)] ( 1 – 7 ). Due to the planary chirality of the unsymmetrically disubstituted cyclopentadienyl iron moiety of fct the complexes 2 – 7 with optically active amino acidate ligands are formed as a mixture of two diastereoisomers, which can be detected by their NMR spectra.