Improved chemical syntheses of 1- and 5-deazariboflavin |
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Authors: | Carlson Erin E Kiessling Laura L |
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Affiliation: | Departments of Chemistry, University of Wisconsin, Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA. |
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Abstract: | The cofactor flavin adenine dinucleotide (FAD) is required for the catalytic activity of a large class of enzymes known as flavoenzymes. Because flavin cofactors participate in catalysis via a number of different mechanisms, isoalloxazine analogues are valuable for mechanistic studies. We report improved chemical syntheses for the preparation of the two key analogues, 5-deazariboflavin and 1-deazariboflavin. |
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