Enantioselective gold-catalyzed functionalization of unreactive sp3 C-H bonds through a redox-neutral domino reaction |
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| Authors: | Zhou Guanghua Liu Feng Zhang Junliang |
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| Institution: | Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China. |
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| Abstract: | Selectivity is golden: The first asymmetric redox-neutral domino reaction catalyzed by gold that results in the direct functionalization of unreactive sp(3) C-H bonds has been reported. This method consists of a heterocyclization/1,5-hydride transfer/cyclization reaction and provides synthetically valuable azepines with high enantioselectivities and in high yields (Tf = triflate; see scheme). |
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| Keywords: | azepines C?H activation enantioselectivity furan gold |
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