Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes |
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| Authors: | Yoshitaka Hamashima Hisashi Takano Yasunori Tsuchiya Tomomi Goto |
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| Institution: | a Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
b RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, 351-0198, Japan |
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| Abstract: | Using chiral palladium enolates as key intermediates, efficient catalytic enantioselective fluorination reactions of active methine compounds have been developed. These reactions can be conducted in alcoholic solvents without any precaution to exclude water and moisture, and various β-ketoesters and β-ketophosphonates were fluorinated in a highly enantioselective manner (up to 98% ee). |
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| Keywords: | Fluorination Palladium β-Ketoesters β-Ketophosphonates Asymmetric catalysis |
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