A new synthesis of the phytotoxin porritoxin |
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Authors: | Anne Moreau Eric Deniau Pierre Grandclaudon |
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Affiliation: | Laboratoire de Chimie Organique Physique, UMR 8009 ‘Chimie Organique et Macromoléculaire’, Bâtiment C3(2), Université des Sciences et Technologie de Lille, F-59655 Villeneuve d'Ascq Cédex, France |
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Abstract: | A convenient synthesis of the phytotoxin porritoxin is described. Central to the approach employed is the formation of the isoindolinone template obtained via a directed lithiation/Parham cyclization process enabling the concomitant connection of an acetal appendage. Further conversion into the requisite hydroxyalkyl chain, selective deprotection, and O-prenylation complete the synthesis of the title compound. |
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Keywords: | Alkaloids Parham procedure Isoindolinones |
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