Synthesis of novel halo-oxybispyridines, new building blocks in cholinergic medicinal chemistry |
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Authors: | Anne Sophie Voisin Jean-Charles Lancelot Sylvain Rault |
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Affiliation: | a Centre d'Etudes et de Recherche sur le Médicament de Normandie, UPRES EA-3915, U.F.R. des Sciences Pharmaceutiques 5, rue Vaubénard, 14032 Caen Cedex, France b BoroChem S.A.S., Immeuble Emergence 7, rue Alfred Kastler, 14000 Caen, France |
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Abstract: | This paper describes a method for the preparation of oxybispyridines bearing several halogens, which could be further transformed into other functional groups thus giving access to libraries with the bis-pyridyl ether moiety as the common structural feature of interest in cholinergic medicinal chemistry. Scope and limitation of the method are outlined. |
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