Synthesis of coumarins by Pt-catalyzed hydroarylation of propiolic acids with phenols期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of coumarins by Pt-catalyzed hydroarylation of propiolic acids with phenols

Authors:	Juzo Oyamada

Affiliation:	Department of Chemistry and Applied Chemistry, Faculty of Science and Engineering, Saga University, Honjo-machi, Saga 840-8502, Japan

Abstract:	Synthesis of coumarins from phenols and propiolic acids was examined by using a Pt catalyst such as PtCl₂/AgOTf, K₂PtCl₄/AgOTf, and K₂PtCl₄/AgOAc. Propiolic acid reacted even with less reactive phenols in trifluoroacetic acid to give coumarins and dihydrocoumarins. In the case of substituted propiolic acids, phenylpropiolic acid and 2-octynoic acid, the reactions proceeded selectively to afford coumarins in good to high yields.

Keywords:	Coumarin Hydroarylation Propiolic acid Platinum catalyst Silver triflate C-H bond functionalization Trifluoroacetic acid
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