Synthesis of coumarins by Pt-catalyzed hydroarylation of propiolic acids with phenols |
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| Authors: | Juzo Oyamada |
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| Affiliation: | Department of Chemistry and Applied Chemistry, Faculty of Science and Engineering, Saga University, Honjo-machi, Saga 840-8502, Japan |
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| Abstract: | Synthesis of coumarins from phenols and propiolic acids was examined by using a Pt catalyst such as PtCl2/AgOTf, K2PtCl4/AgOTf, and K2PtCl4/AgOAc. Propiolic acid reacted even with less reactive phenols in trifluoroacetic acid to give coumarins and dihydrocoumarins. In the case of substituted propiolic acids, phenylpropiolic acid and 2-octynoic acid, the reactions proceeded selectively to afford coumarins in good to high yields. |
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| Keywords: | Coumarin Hydroarylation Propiolic acid Platinum catalyst Silver triflate C-H bond functionalization Trifluoroacetic acid |
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