Sesterterpene metabolites from the sponge Hyatella intestinalis |
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Authors: | Claudia J. Herná ndez-Guerrero,Eva Zubí a,Marí a J. Ortega |
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Affiliation: | a Departamento de Química Orgánica, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Apdo. 40, 11510-Puerto Real, Cádiz, Spain b Instituto de Ciencias del Mar y Limnología, UNAM, Apdo. 811, Mazatlán 82000, Sinaloa, Mexico |
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Abstract: | The sponge Hyatella intestinalis from the Gulf of California contains the new scalarane-related sesterterpenes hyatelones A-C and hyatolides A-B, together with the new scalaranes hyatolides C-E, hyatelactam, 12-O-deacetyl-19-epi-scalarin and the new norscalarane 12-O-deacetylnorscalaral B. The structures of the new metabolites have been established by spectroscopic analysis of the natural products and, in some instances, of their acetyl derivatives. The new compounds hyatelone A, 19,20-di-O-acetylhyatelone B, hyatolide A, 20-O-acetylhyatolide C, hyatelactam, and 12-O-deacetylnorscalaral B have shown activity as growth inhibitors of several tumor cell lines. |
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Keywords: | Natural products Sponges Sesterterpenes Structure determination Cytotoxicity |
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