Optimisation and scale-up of microwave assisted cyanation |
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| Authors: | Michael R Pitts Peter McCormack John Whittall |
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| Institution: | StylaCats Ltd, The Heath Business & Technology Park, Runcorn, Cheshire, WA7 4QX, UK |
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| Abstract: | A microwave enhanced palladium catalysed cyanation procedure was optimised for the final step of a production method for citalopram 2. The method was demonstrated on multigram batch scale for the synthesis of escitalopram (S)-2 and then in a stop-flow continuous process for citalopram. |
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| Keywords: | Microwave assisted chemistry Cyanation Citalopram Palladium catalysis |
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