Synthesis and anti-tubulin evaluation of chromone-based analogues of combretastatins |
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Authors: | Jérôme Quintin Sylviane Thoret |
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Institution: | a Laboratoire de Pharmacognosie, (BIOCIS, UMR-8076 CNRS), Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France b CNRS-ICSN, UPR 2301, 91190 Gif-sur-Yvette, France |
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Abstract: | Twenty new hybrid compounds with both combretastatin and flavone moieties were synthesized. These derivatives are classified according to the position of the trimethoxyphenyl ring at C-2 or C-3 of the chromone and presence or absence of a carbonyl as a linker between C-3 and the aryl ring. Most of these compounds were prepared from hesperidin or naringin, two natural and abundant Citrus flavonoids. Seven of these combretastatin analogues revealed anti-tubulin activity but in a medium range. |
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Keywords: | Flavones Citrus flavonoids Combretastatins Tubulin |
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