An efficient Negishi cross-coupling reaction catalyzed by nickel(II) and diethyl phosphite |
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Authors: | Andrei Gavryushin |
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Institution: | Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13 Haus F, 81377 München, Germany |
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Abstract: | A combination of diethyl phosphite-DMAP and Ni(II) salts forms a very effective catalytic system for the cross-coupling reactions of arylzinc halides with aryl, heteroaryl, and alkenyl bromides, chlorides, triflates, and nonaflates. The choice of solvent is quite important and the mixture of THF-N-ethylpyrrolidinone (NEP) (8:1) was found to be optimal. The reaction usually requires only 0.05 mol % of NiCl2 or Ni(acac)2 as catalyst and proceeds at room temperature within 1-48 h. |
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