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Synthesis of cyclic dienamide using ruthenium-catalyzed ring-closing metathesis of ene-ynamide |
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| Authors: | Miwako Mori Hideaki Wakamatsu Yukako Sato Yoshihiro Sato |
| Affiliation: | a Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan b Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan c Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan |
| Abstract: | Ring-closing metathesis of ene-ynamide, which has alkene and ynamide moieties in a molecule, using a second-generation ruthenium carbene complex produced nitrogen-containing heterocycles, which have a dienamide moiety, in high yields. Diels-Alder reaction of the cyclized product with dienophile proceeded smoothly to give an indole or quinoline derivative in high yield. |
| Keywords: | Ene-ynamide Dienamide Enyne metathesis Indole Quinoline Ethylene |
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