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Synthesis of N-alkyl substituted bioactive indolocarbazoles related to Gö6976 |
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| Authors: | Sudipta Roy Gordon W. Gribble |
| Affiliation: | a Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA b Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA |
| Abstract: | The syntheses of new nitrile and amide analogues of 7-keto Gö6976 are described. The amide analogue 22 was formed via the condensation with a new functionalized indoleacetic acid derivative 25 to overcome the solubility problem during the coupling reaction. |
| Keywords: | Indolocarbazoles Bisindolylmaleimide Gö 6976 UCN-01 Checkpoint inhibitors |
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