Synthesis of cyclic bis(3′-5′)diguanylic acid (c-di-GMP) analogs |
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Authors: | Mamoru Hyodo |
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Institution: | Graduate School of Information Science/Human Informatics and CREST JST, Nagoya University, Chikusa, Nagoya 464-8601, Japan |
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Abstract: | This paper reports the synthesis of cyclic bis(3′-5′)diguanylic acid (c-di-GMP) analogs, including the monophosphorothioic acid of c-di-GMP (c-GpGps), cyclic bis(3′-5′)guanylic/adenylic acid (c-GpAp), and cyclic bis(3′-5′)guanylic/inosinic acid (c-GpIp). These compounds are expected to be important, both in elucidating the mechanism of bioactive c-di-GMP and in designing and creating new bioactive c-di-GMP-related artificial derivatives. |
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Keywords: | Nucleotides Phosphoramidites Cyclization c-Di-GMP |
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