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On the importance of the pore inner cavity for the ionophoric activity of 1,3-alternate calix[4]arene/steroid conjugates |
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| Authors: | Irene Izzo Nakia Maulucci Agostino Casapullo Paolo Tecilla |
| Institution: | a Department of Chemistry, University of Salerno, via S. Allende, Baronissi, I-84081 Salerno, Italy b Department of Pharmaceutical Science, University of Salerno, Via Ponte Don Melillo, Fisciano, I-84084 Salerno, Italy c Department of Chemical Sciences, University of Trieste, via L. Giorgieri, I-34127 Trieste, Italy |
| Abstract: | 1,3-Alternate calix4]arenes, decorated with four nonpolar ‘all-trans’ tetracyclic nuclei and cation-stabilizing β-methoxyethoxy appendages, were synthesized from commercially available starting materials and through straightforward functional groups transformations/couplings. Their Na+-transport activities, when compared with those exerted by the known conformationally-rigidified 1,3-alternate calix4]arene AB/cis cholic acid conjugates, suggest that the cation conductance is related to the morphology of the pendant steroids. |
| Keywords: | Ionophores Amphiphiles Steroids Calix[4]arenes |
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