The Ugi reaction with 2-substituted cyclic imines. Synthesis of substituted proline and homoproline derivatives |
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Authors: | Valentine G Nenajdenko Anton V Gulevich Elizabeth S Balenkova |
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Institution: | Department of Chemistry, Moscow State University, Leninskije gory, 119899 Moscow, Russia |
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Abstract: | The Ugi three-component reaction with 2-substituted five-, six-, and seven-membered cyclic imines was investigated. The reaction opens a new route to substituted proline and homoproline derivatives. It was shown that the method is efficient for the one-step preparation of seminatural dipeptides containing natural amino acid residues, and fragments of substituted proline or pipecolinic acid. The scope and limitation of the approach are discussed. |
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Keywords: | Ugi reaction Multicomponent reaction Imine Amino acid Isocyanide Proline Homoproline Peptide |
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