1,3-Dimethyl-2-(3-nitro-1,2,4-triazol-1-yl)-2-pyrrolidin-1-yl-1,3,2-diazaphospholidinium hexafluorophosphate (MNTP): a powerful condensing reagent for phosphate and phosphonate esters |
| |
Authors: | Natsuhisa Oka |
| |
Institution: | Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa, Chiba 277-8562, Japan |
| |
Abstract: | A novel phosphonium-type condensing reagent, 1,3-dimethyl-2-(3-nitro-1,2,4-triazol-1-yl)-2-pyrrolidin-1-yl-1,3,2-diazaphospholidinium hexafluorophosphate (MNTP), was designed and synthesized. A 31P NMR study on the condensation reactions of phosphate, alkylphosphonate, boranophosphate, and H-phosphonate derivatives with an alcohol in the presence of MNTP demonstrated the versatility and the enhanced activity of the new condensing reagent, compared to the previously reported phosphonium-type condensing reagents. The mechanism of the condensation reactions mediated by MNTP is discussed on the basis of the 31P NMR studies and theoretical calculations. |
| |
Keywords: | Phosphonium-type condensing reagent Phosphate Alkylphosphonate Boranophosphate H-Phosphonate |
本文献已被 ScienceDirect 等数据库收录! |
|