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Synthesis of original thiazoloindolo[3,2-c]quinoline and novel 8-N-substituted-11H-indolo[3,2-c]quinoline derivatives from benzotriazoles. Part I
Authors:Anne Beauchard  Sourisak Sinbandhit  Valérie Thiéry  Thierry Besson
Institution:a Laboratoire de Biotechnologies et Chimie Bio-organique, FRE CNRS 2766, Université de La Rochelle, Avenue Michel Crépeau, 17042 La Rochelle, France
b Centre Régional de Mesures Physiques de l'Ouest, Université de Rennes 1, 35042 Rennes, France
Abstract:Synthesis of novel thiazoloindolo3,2-c]quinoline and 8-substituted-11H-indolo3,2-c]quinolines was performed via Graebe-Ullmann thermal cyclization from appropriated N-arylated benzotriazoles. 7H-4,7-Diaza-benzode]anthracene, a by-product reaction structurally closed to pyridoacridine skeleton was also identified.
Keywords:Indoloquinoline  Benzotriazoles  Fused ring systems  Graebe-Ullmann  Microwaves
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