Ruthenium-catalyzed [2+2] cycloadditions of bicyclic alkenes and ynamides |
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| Authors: | Karine Villeneuve William Tam |
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| Institution: | Department of Chemistry, Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, University of Guelph, Guelph, Ont., Canada N1G 2W1 |
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| Abstract: | Ruthenium-catalyzed 2+2] cycloadditions between bicyclic alkenes and ynamides were investigated. The ynamide moiety was found to be compatible with the ruthenium-catalyzed cycloaddition conditions giving the corresponding cyclobutene cycloadducts in moderate to good yields (up to 97%). Diastereoselective cycloaddition utilizing chiral cyclic ynamides were also examined and a low to moderate level of asymmetric induction was observed. |
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| Keywords: | Ynamines Cycloaddition Amidation |
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