One-pot synthesis of chiral dehydroproline esters: [3+2]-type cycloaddition reaction of allenylstannane and α-imino ester |
| |
| Authors: | Kohei Fuchibe |
| |
| Institution: | Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan |
| |
| Abstract: | An enantioselective 3+2]-type cycloaddition of allenylstannane and α-imino ester was developed. Synthetic utility of the 4-stannyldehydroproline ester intermediate was demonstrated: iodine oxidation and Stille coupling reaction of the intermediate afforded optically active 4-iodo- and 4-aryldehydroproline esters in good yields and in high ees, respectively. |
| |
| Keywords: | Allenylstannane Annulation Asymmetric synthesis α-Imino ester Iodine oxidation Proline Stille coupling |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
