Synthesis of naturally occurring polyacetylenes via a bis-silylated diyne |
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Authors: | Vito Fiandanese Daniela Bottalico Giuseppe Marchese Angela Punzi |
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Affiliation: | Dipartimento di Chimica, Università di Bari, via E. Orabona 4, 70126 Bari, Italy |
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Abstract: | A straightforward synthesis of a series of naturally occurring polyacetylenes has been developed, including the montiporynes A and C, possessing cytotoxic activity against several human solid tumor cells, the atractylodin, with antibiotic activity against Escherichia coli, and triynes, which display insecticidal activities, starting from the readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne. |
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Keywords: | Silicon and compounds Polyacetylenes Coupling reactions Bioactive products |
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