Nickel(0)-mediated [2+2+1] cyclization reaction of chromium carbene complexes and internal alkynes |
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Authors: | José Barluenga Pablo Barrio Lorena Riesgo Luis A López Miguel Tomás |
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Institution: | Instituto Universitario de Química Organometálica ‘Enrique Moles’, Unidad Asociada al C.S.I.C., Universidad de Oviedo, Julián Clavería 8, Oviedo 33006, Spain |
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Abstract: | Alkyl, aryl, and heteroaryl chromium Fischer carbene complexes undergo Ni(0)-mediated 2+2+1] cyclization reaction with internal unactivated and electron-poor internal alkynes to yield highly substituted cyclopentadienes with complete regioselectivity in most cases. The intramolecular version of this cyclization has been accomplished with 1,8-diphenyl-1,7-octadiyne to produce indene derivatives. This three-component 2+2+1] cyclization represents a very uncommon process in the chemistry of Fischer carbene complexes. |
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Keywords: | Carbene complexes Chromium(0) Nickel(0) Carbene transfer Alkynes Cyclopentadienes Three-component process |
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