Access to substituted thiapyrrolizidinones and fused pyridones using the domino N-acyliminium-thionium equilibrium/1,3-dipolar cycloaddition/desulfurization cyclization cascade |
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| Authors: | Abdulkareem Hamid Adam Daïch |
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| Institution: | a Laboratoire de Chimie, URCOM, EA 3221, UFR des Sciences & Techniques de l'Université du Havre, B.P: 540, 25 rue Philippe Lebon, F-76058 Le Havre Cedex, France
b IRCOF-UMR 6014 CNRS, Place Emile Blondel, Université de Rouen, F-76131 Mt-St-Aignan Cedex, France |
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| Abstract: | Substituted thiapyrrolizidinones and fused pyridones, and quinolizinones were reported efficaciously from suitable thioamides in yields ranging from 30% to 65%. The reaction proceeded in a one-pot procedure as cascade process by the intramolecular 1,3-dipolar cycloaddition of thioisomünchnones followed by desulfurization of the adducts. During these investigations, the mechanistic aspects of the process were also discussed. |
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| Keywords: | Thioisomü nchnone 1 3-Dipolar cycloaddition Thioamide Heterocycle Domino process Lawesson's Thionation One-pot procedure |
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