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Trypanocidal constituents of Dracocephalum komarovi |
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| Authors: | Nahoko Uchiyama Fumiyuki Kiuchi Gisho Honda Yoshio Takeda Ozodbek A Ashurmetov |
| Institution: | a Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan b Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, 1-2 Hachimandai, Tsukuba 305-0843, Japan c Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan d Scientific Production Center ‘Botanika’ of Uzbek Academy of Sciences, Tashkent 700143, Uzbekistan e Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe-city, Kyoto 610-0395, Japan |
| Abstract: | Trypanocidal constituents of Dracocephalum komarovi were investigated. Under guidance of the in vitro trypanocidal activity against epimastigotes of Trypanosoma cruzi, the causative agent of Chagas' disease, two new diterpenes, dracocequinones A (1) and B (2), and two known triterpene acids, ursonic acid and ursolic acid, were isolated as trypanocidal constituents, in addition to previously reported diterpenes, cyclocoulterone (4), komaroviquinone (5), dracocephalone A (6) and komarovispirone (7). Furthermore a new diterpene, komarovinone A (3), was isolated, together with four known terpenes. Among these compounds, komaroviquinone (5) showed the most potent activity with minimum lethal concentration of 0.4 μM. Structure elucidation of the new diterpenes 1-3 was described. |
| Keywords: | Dracocephalum komarovi Diterpene Trypanosoma cruzi Trypanocidal activity |
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