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Synthesis of functionalized 3-spirocyclopropane-2-indolones from isomerised Baylis-Hillman adducts of isatin |
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| Authors: | Ponnusamy Shanmugam Vadivel Vaithiyanathan Baby Viswambharan |
| Affiliation: | Chemical Sciences and Technology Division, Regional Research Laboratory (CSIR), Thiruvananthapuram 695 019, Kerala, India |
| Abstract: | A facile, high yield stereoselective synthesis of functionalized diastereomeric 3-spirocyclopropane-2-indolones (10-17a,b) from the isomerised bromo derivatives of Baylis-Hillman adducts of isatin(2-9a,b) by reductive cyclization with sodium borohydride is reported. |
| Keywords: | Isatin Spirocyclopropane Sodium borohydride 2-Indalones Baylis-Hillman adduct |
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