Synthesis of trans-vaccenic acid and cis-9-trans-11-conjugated linoleic acid |
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| Authors: | Patricia E. Duffy Helen M. Roche |
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| Affiliation: | a Centre for Synthesis and Chemical Biology, School of Chemistry, Trinity College, University of Dublin, Dublin 2, Ireland
b Nutrigenomics Research Group, Department of Clinical Medicine, Institute of Molecular Medicine, St. James' Hospital, Dublin 8, Ireland |
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| Abstract: | The preparation of the monounsaturated fatty acid, trans-vaccenic acid 4 (TVA), using both Wittig and one-pot Julia-Kocieński olefination protocol, was achieved in good yield. Similarly a Wittig approach was employed for the stereoselective synthesis of cis-9-trans-11-conjugated linoleic acid 2 from trans-2-nonenal and (8-carboxyoctyl)triphenylphosphonium bromide 12. |
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