Institution: | a Medicinal Chemistry 1, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts. SG1 2NY, UK b School of Chemistry, The University of Manchester, Manchester M13 9PL, UK c AstraZeneca Process R&D, Avlon Works, Severn Road, Hallen Bristol BS10 7ZE, UK |