| Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine |
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| 作者姓名： | Chao Jie WANG Jian Hong WANG Ying GAN Zhi Yong CHEN Gang Jun DU Jin ZHAO |
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| 作者单位： | Chao Jie WANG1，Jian Hong WANG2，Ying GAN1，Zhi Yong CHEN1，Gang Jun DU3，Jin ZHAO1 1College of Chemistry and Chemical Technology，Henan University，Kaifeng 475001 2Key Lab of Special Function Material，Henan University，Kaifeng 475001 3Medical College of Henan Unversity，Kaifeng 475001 |
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| 基金项目： | 国家自然科学基金;河南省自然科学基金 |
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| 摘 要： | Chemotherapy is one of the most important treatments of cancer, however, clinical use of conventional anticancer drugs is often limited by their side effects such as toxicity for normal tissues and multidrug resistance of tumor cells1, 2. Because of the s…
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| 关 键 词： | 原位合成 抗癌活性 茄呢哌嗪三元胺 协同效应 |
| 收稿时间： | 04 29 2006 12:00AM |
Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine |
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| Chao Jie WANG Jian Hong WANG Ying GAN Zhi Yong CHEN Gang Jun DU Jin ZHAO.Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine[J].Chinese Chemical Letters,2006,17(10):1301-1304. |
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| Authors: | Chao Pie WANG Jian Hong WANG Ying GAN Zhi Yong CHEN Gang Jun DU Jin ZHAO |
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| Abstract: | A series of novel antitumor agents-the solanesylpiperazinotriamine derivatives were designed and synthesized, their structures were confirmed by IR,^ 1H-NMR, MS, and element analysis. The preliminary tests showed that at low micromolar concentrations these compounds exhibited obvious toxicity on tumor cells in vitro, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations they also evidently enhanced the curative effect of vincristine. |
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| Keywords: | Solanesylpiperazinotriamine antitumor activity synergistic effect |
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