Studies directed towards the total synthesis of botcinic acid, the revised structure of botcinolide: synthesis of the highly substituted tetrahydropyran moiety |
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Authors: | Tushar Kanti Chakraborty Rajib Kumar Goswami |
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Institution: | Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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Abstract: | Synthesis of the highly substituted polyoxygenated tetrahydropyran ring of botcinic acid, the revised structure of botcinolide is achieved using, as key steps, a highly stereoselective aldol reaction of the titanium enolate from a lactate-derived chiral ketone and a stereoselective dihydroxylation. |
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Keywords: | Botcinolides Botcinic acid Dihydroxylation Aldol reaction Sharpless epoxidation |
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