Synthesis and Crystal Structure of a New 3-Amino-3-deoxy Derivative from 3-Keto-D-xylose

The title compound 2 was synthesized by the reaction of 3-keto-D-xylose with O-C6H4NH2NH2 and characterized by IR, NMR and HRMS, and its crystal structure was determined by X-ray diffraction analysis. The crystal is of orthorhombic system (C21H22N2O5, Mr =382.41), space group P212121 with a = 10.140(2), b = 10.802(2), c = 17.840(4) (A°), β= 90°, V=1954.1 (7) (A°)3, Z = 4, Dc = 1.300 g/cm3, F(000) = 808,μ= 0.094 mm-1, the final R = 0.0354 and wR =0.0514 for 1924 observed reflections (I > 2σ(I)). One intermolecular and one intramolecular hydrogen bonds were found. The absolute configuration of this molecule was confirmed by comparison with that of the original material.