Novel derivatives of 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles and their pharmacological evaluation as CB1 cannabinoid ligands |
| |
Authors: | Laura Hernandez-Folgado Pilar Goya Jordi Frigola María Rosa Cuberes Alberto Dordal Jörg Holenz Nadine Jagerovic |
| |
Affiliation: | (1) Instituto de Química Médica (CSIC), Juan de la Cierva, Madrid, Spain;(2) Laboratorios del Dr. Esteve S. A., Barcelona, Spain |
| |
Abstract: | In a previous study, we have identified 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles to be a novel class of cannabinoid type-1 (CB1) receptor antagonists. However, the synthesis yields for the ligands were low. Here we present an alternative synthesis pathway with improved yields. In addition, we have synthezised new structural derivatives and studied their results in competitive radioligand binding assays for cannabinoid receptors. Correspondence: Nadine Jagerovic, Instituto de Química Médica (CSIC), Juan de la Cierva 3, E-28006-Madrid, Spain. |
| |
Keywords: | Cannabinoid 1,2,4-Triazole Binding. |
本文献已被 SpringerLink 等数据库收录! |
|