Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathway |
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| Authors: | Wen-Li Gu Sai-Li Fu Yan-Xia Wang Ying Li He-Zuo Lü Xiao-Ming Xu Pei-Hua Lu |
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| Institution: | (1) Department of Neurobiology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, PR China;(2) Department of Clinical Laboratory, No.9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 200011 Shanghai, PR China;(3) Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, 46202 Indianapolis, IN, USA |
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| Abstract: | Background Neural precursor cells (NPCs) are defined by their ability to proliferate, self-renew, and retain the potential to differentiate
into neurons and glia. Deciphering the factors that regulate their behaviors will greatly aid in their use as potential therapeutic
agents or targets. Chondroitin sulfate proteoglycans (CSPGs) are prominent components of the extracellular matrix (ECM) in
the central nervous system (CNS) and are assumed to play important roles in controlling neuronal differentiation and development. |
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