呼吸机相关性肺炎患者肺部超声评分与NAMPT、Endocan、NLR的关系

本文探讨了呼吸机相关性肺炎患者肺部超声评分(LUS)与外周血烟酰胺磷酸核糖转移酶(NAMPT)、内皮细胞特异性分子-1(Endocan)、中性粒细胞/淋巴细胞值(NLR)的关系。选取呼吸机相关性肺炎患者80例(观察组)和非呼吸机相关性肺炎患者40例(对照组),采用酶联免疫吸附试验检测患者外周血NAMPT、Endocan,自动血细胞分析仪检测NLR。分析结果显示,观察组通气24 h、48 h和72 h时NAMPT、Endocan和NLR均高于对照组(P<0.05),此外,观察组死亡患者NAMPT、Endocan、NLR和LUS及变化值高于存活患者(P<0.05),上述指标联合预测患者死亡的AUC值高于各指标单独预测(P<0.05)。说明呼吸机相关性肺炎患者LUS变化与外周血NAMPT、Endocan、NLR呈正相关,联合预测患者预后有一定的应用价值。

Correlation between Lung Ultrasound Score and Peripheral Blood Concentrations of NAMPT,Endocan and NLR in Patients with Ventilator-associated Pneumonia

This study investigated the correlation between pulmonary ultrasound score(LUS) and peripheral blood nicotinamide phosphoribosyl transferase(NAMPT), endothelial cell specific molecule-1(Endocan), neutrophil/lymphocyte ratio(NLR) in patients with ventilator-associated pneumonia. There were 80 cases of ventilator-associated pneumonia(observation group) and 40 cases of non-ventilator-associated pneumonia(control group), enzyme linked immunosorbent assay was used to detect NAMPT and Endocan in peripheral blood, and automatic blood cell analyzer was used to detect NLR. The results showed that the serum NAMPT, Endocan and NLR in the observation group were significantly higher than those in the control group(P<0.05). Serum NAMPT, Endocan, NLR and LUS and changes in dead patients were significantly higher than surviving patients in the observation group(P<0.05). The area under the ROC curve of NAMPT, Endocan, NLR change combined with LUS change to predict the death of patients was significantly higher than that of each index score change alone(P<0.05).Therefore,the change of LUS of patients with severe ventilator-associated pneumonia is positively correlated with the change of NAMPT,Endocan,NLR concentration in peripheral blood,and the combined prediction of prognosis of patients has certain application value.