Rapid two-step synthesis of mitrin from heparosan: a replacement for heparin |
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Authors: | Kuberan Balagurunathan Beeler David L Lawrence Roger Lech Miroslaw Rosenberg Robert D |
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Institution: | Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. |
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Abstract: | We have engineered a two-step enzymatic synthesis of Mitrin which is a more potent and homogeneous anticoagulant than the current animal-derived heparin. This engineered heparin may have advantages of being free from animal-derived pathogens and may also have reduced side effects such as heparin induced thrombocytopenia. This approach can also be extended to tailor heparin-based drugs with improved therapeutic characteristics to treat other disorders or infections in which heparin-like molecules play a major role. |
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