Comparative quantitative study of DDT and its metabolites in human milk by gas chromatography with electron capture and mass spectrometric detection |
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| Authors: | I Al-Saleh M Al-Zahrani M Al-Shanshoury G Mohammed N Shinwari I Al-Doush P Basile |
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| Institution: | (1) Biological and Medical Research Department (MBC#03), King Faisal Specialist Hospital & Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia;(2) Department of Preventive Medicine, Ministry of Health, P.O. Box 2903, 11461 Riyadh, Saudi Arabia;(3) Biostatistics, Epidemiology and Scientific Computing Department (MBC#03), King Faisal Specialist Hospital and Research Center, P.O. Box 3354, 11211 Riyadh, Saudi Arabia |
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| Abstract: | Summary Comparative analytical quantitation of DDE, DDD, and DDT in human milk, by gas chromatography with mass spectrometric and
electron capture detection (GC-MS and GC-ECD) has been studied by use of 513 samples of milk from lactating mothers participating
in a World Health Organization special study. Although Correlation between thep,p-DDE concentrations measured by GC-ECD and GC-MSD was excellent (r=0.950,P<0.0001) and correlation was significant and moderate forp,p-DDD andp,p-DDT, the best precision was obtained by use of GC-MS. This study has therefore demonstrated that GC-MSD is a useful tool
for determining the concentration of DDT and its metabolites, because it enables simultaneous detection and confirmation. |
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| Keywords: | Gas chromatography ECD and mass spectrometric detection Breast milk DDT and DDE |
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