Dual mechanisms of DNA damage by MoCH(3)(eta(3)-allyl)(CO)(2)(phen) complexes |
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| Authors: | Mohler Debra L Shell Jennifer R Coonce Janet G Mirandi Jessica L Riera Lucía Cuesta Luciano Pérez Julio |
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| Institution: | Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA. mohlerdl@jmu.edu |
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| Abstract: | DNA damage by MoCH3(eta3-allyl)(CO)2(phen) complexes has been shown to occur by two mechanisms: by backbone cleavage via the abstraction of H1' and/or H5' from the deoxyribose moiety and by base modification, resulting in G-specific cleavage via the formation of base-labile residues methylguanine, methoxyguanine, and 8-oxo-G. |
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