| Efficient Synthesis of 2—Ethyl—A—ring Analogues of 19—Nor—1α,25—dihydroxy Vitamin D3 |
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| 作者姓名： | WangQiu-an ZHAOYu-rui |
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| 作者单位： | [1]ColllegeofchemistryandChemicalEngineering,HunanUniversity,Changsha410082,P.R.China [2]DepartmentofOrganicChemistry,UniversityofGent,Krijgslaan281S4,B-9000Gent,Belgium |
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| 摘 要： | The novel 19-nor-1α,25-dihydroxy vitamin D3 analogues possessing an ethyl at the 2-position(4 and 5).were synthesized by coupling 25-hydroxy Windaus-Grundmann ketone derivative 20 with A-ring synthons(15 and 19)respectively.The enantioselective synthesis of substituted bicyclic3,1,0]hexanes structure A-ring synthons,started from all-cis-3,5-dihydroxy-4-ethyl-1-(methoxycarbonyl)cyclohexane via lipase-catalyzd asymmetrization,was demonstratcd.
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| 关 键 词： | 维生素D3 乙烷基环状物 类似物 合成 |
Efficient Synthesis of 2-Ethyl-A-ring Analogues of 19-Nor-1α,25-dihydroxy Vitamin D3 |
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| WangQiu-an ZHAOYu-rui.Efficient Synthesis of 2-Ethyl-A-ring Analogues of 19-Nor-1α,25-dihydroxy Vitamin D3[J].Chemical Research in Chinese University,2003,19(2):165-173. |
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| Authors: | WANG Qiuan ZHAO Yu-rui |
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| Abstract: | The novel 19-nor-lα,25-dihydroxy vitamin D3 analogues possessing an ethyl at the 2-position(4 and 5), were synthesized by coupling 25-hydroxy Windaus-Grundmann ketone derivative 20 with A-ring synthons(15 and 19) respectively. The enantioselective synthesis of substituted bicyclic3,1,0] hexanes structure A-ring synthons, started from all-cis-3,5-dihydroxy-4-ethyl-1-(methoxycarbonyl)cyclohexane via lipase-catalyzd asymmetrization, was demonstrated. |
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| Keywords: | 25-dihydroxy vitamin D3 Synthesis Lipase-catalyzed Asymmetrization |
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