Overcoming the Limitations of C−H Activation with Strongly Coordinating N‐Heterocycles by Cobalt Catalysis |
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Authors: | Hui Wang Dr Mélanie M Lorion Prof?Dr Lutz Ackermann |
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Institution: | 1. http://www.ackermann.chemie.uni‐goettingen.de/;2. Institut für Organische und Biomolekulare Chemie, Georg-August-Universit?t G?ttingen, G?ttingen, Germany |
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Abstract: | Strongly coordinating nitrogen heterocycles, including pyrimidines, oxazolines, pyrazoles, and pyridines, were fully tolerated in cobalt‐catalyzed C?H amidations by imidate assistance. Structurally complex quinazolines are thus accessible in a step‐economic manner. Our findings also establish the relative powers of directing groups in cobalt(III)‐catalyzed C?H functionalization for the first time. |
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Keywords: | C− H activation cobalt directing groups heterocycles imidates |
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