Copper‐Catalyzed Carbonylative Coupling of Cycloalkanes and Amides |
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Authors: | Yahui Li Dr Kaiwu Dong Fengxiang Zhu Zechao Wang Prof?Dr Xiao‐Feng Wu |
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Institution: | 1. Leibniz-Institut für Katalyse e.V. an der Universit?t Rostock, Rostock, Germany;2. Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, P.R. China |
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Abstract: | Carbonylation reactions are a most powerful method for the synthesis of carbonyl‐containing compounds. However, most known carbonylation procedures still require noble‐metal catalysts and the use of activated compounds and good nucleophiles as substrates. Herein, we developed a copper‐catalyzed carbonylative transformation of cycloalkanes and amides. Imides were prepared in good yields by carbonylation of a C(sp3)?H bond of the cycloalkane with the amides acting as weak nucleophiles. Notably, this is the first report of copper‐catalyzed carbonylative C?H activation. |
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Keywords: | amides carbonylation copper catalysis cycloalkanes imides |
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