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C−C Coupling of Benzyl Fluorides Catalyzed by an Electrophilic Phosphonium Cation |
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| Authors: | Dr. Jiangtao Zhu Dr. Manuel Pérez Prof. Dr. Douglas W. Stephan |
| Affiliation: | Department of Chemistry, University of Toronto, Toronto, Ontario, Canada |
| Abstract: | The activation and cleavage of benzyl fluorides by the electrophilic organofluorophosphonium catalyst, [(C6F5)3PF][B(C6F5)4], is reported and used for the preparation of 1,1‐diarylalkanes (37 examples) and substituted aryl homoallylic alkenes (14 examples). This procedure involves mild conditions, avoids harmful waste, and is compatible with a range of substituted arenes and allylic silanes. |
| Keywords: | arylation reactions benzyl fluorides C(sp3)– C(sp3) coupling homogeneous catalysis phosphonium cations |