An Iridium(I) N‐Heterocyclic Carbene Complex Catalyzes Asymmetric Intramolecular Allylic Amination Reactions |
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| Authors: | Dr Ke‐Yin Ye Qiang Cheng Dr Chun‐Xiang Zhuo Prof Li‐Xin Dai Prof?Dr Shu‐Li You |
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| Institution: | 1. http://shuliyou.sioc.ac.cn/;2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China;3. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China |
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| Abstract: | A chiral iridium(I) N‐heterocyclic carbene complex was reported for the first time as the catalyst in the highly enantioselective intramolecular allylic amination reaction. The current method provides facile access to biologically important enantioenriched indolopiperazinones and piperazinones in good yields (74–91 %) and excellent enantioselectivities (92–99 % ee). Preliminary mechanistic investigations reveal that the C?H activation occurs at the position ortho to the N‐aryl group of the ligand. |
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| Keywords: | allylic compounds asymmetric catalysis enantioselectivity iridium N-heterocyclic carbenes |
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