Selective Oxytrifluoromethylation of Allylamines with CO2 |
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| Authors: | Jian‐Heng Ye Lei Song Prof. Dr. Wen‐Jun Zhou Tao Ju Zhu‐Bao Yin Si‐Shun Yan Zhen Zhang Dr. Jing Li Prof. Dr. Da‐Gang Yu |
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| Affiliation: | 1. http://chem.scu.edu.cn/en/DaGangYu 0000-0002-4932-0414 Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, P.R. China;2. Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, P.R. China;3. College of Chemistry and Chemical Engineering, Neijiang Normal University, Neijiang, P.R. China |
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| Abstract: | Reported is the first oxy‐trifluoromethylation of allylamines with carbon dioxide (CO2) using copper catalysis, thus leading to important CF3‐containing 2‐oxazolidones. It is also the first time CO2, a nontoxic and easily available greenhouse gas, has been used to tune the difunctionalization of alkenes from amino‐ to oxy‐trifluoromethylation. Of particular note, this multicomponent reaction is highly chemo‐, regio‐, and diastereoselective under redox‐neutral and mild reaction conditions. Moreover, these reactions feature good functional‐group tolerance, broad substrate scope, easy scalability and facile product diversification. The important products could also be formed with either spirocycles or two adjacent tetrasubstituted carbon centers. |
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| Keywords: | carbon dioxide copper fluorine heterocycles reaction mechanisms |
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