HYPOCRELLIN, FROM HYPOCRELLA BAMBUASE, IS PHOTOTOXIC TO HUMAN IMMUNODEFICIENCY VIRUS |
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| Authors: | J. B. Hudson J. Zhou J. Chen L. Harris L. Yip G. H. N. Towers |
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| Affiliation: | Department of Pathology, University of British Columbia, Vancouver, B.C., Canada V5Z 1M9;Provincial AIDS Laboratory, Vancouver, B.C., Canada;Institute of Botany, Chinese Academy of Science, Kunming, Yunnan, China;Department of Botany, University of British Columbia, Vancouver, B.C., Canada |
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| Abstract: | Abstract Hypocrellin, a photodynamic perylene quinonoid isolated from the Chinese medicinal fungus Hypocrella bambuase , was evaluated for antiviral activity against the human immunodeficiency virus (HIV-1). Hypocrellin was phototoxic to HIV-1, almost as good as the structurally similar plant pigment hypericin, and like hypericin its activity required visible light. In contrast peroxyhypocrellin had little or no effect on the virus. |
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