Antioxidant behaviour of 2′‐hydroxy‐chalcones: a study of their electrochemical properties |
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| Authors: | Olga Serifi Fotios Tsopelas Anna‐Maria Kypreou Maria Ochsenkühn‐Petropoulou Panagiotis Kefalas Anastasia Detsi |
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| Affiliation: | 1. Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, , 15780 Athens, Greece;2. Laboratory of Inorganic and Analytical Chemistry, School of Chemical Engineering, National Technical University of Athens, , 15780 Athens, Greece;3. Department of Food Quality and Chemistry of Natural Products, Mediterranean Agronomic Institute of Chania, [Centre International de Hautes Etudes Agronomiques Méditerranéennes], , 73100 Chania, Crete, Greece |
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| Abstract: | The electrochemical behaviour of 13 chalcone analogues was systematically studied by means of cyclic voltammetry and chronoamperometry at a glassy carbon (GC), gold and platinum working electrodes using two different supporting electrolyte/solvent combinations. It was found that chalcone analogues can be easily oxidized at both GC and gold working electrodes, but not at a platinum electrode. Principal component analysis was further employed to reveal similarities/dissimilarities between oxidation potentials, chronoamperometric signals and ability of the compounds to scavenge the reactive oxygen species H2O2. The study reveals the inverse proportional relationship between the scavenging ability of H2O2, expressed as IC50, and chronoamperometric signal at 800 mV using gold as working electrode. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | chalcones cyclic voltammetry chronoamperometry antioxidant activity H2O2 scavenging ability |
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