Antioxidising activity of cinnamic acid derivatives against oxidative stress induced by oxidising radicals |
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| Authors: | Pedro M P Santos Abel J S C Vieira |
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| Institution: | 1. Unidade de Física e Aceleradores, IST/ITN, Instituto Superior Técnico, Universidade Técnica de Lisboa, , 2686‐953 Sacavém, Portugal;2. REQUIMTE, CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, , 2829‐516 Caparica, Portugal |
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| Abstract: | Cinnamic acid and its derivatives react with hydroxyl radical (HO?), in neutral medium, to give hydroxylation products, whether on the benzene ring or on the exocyclic chain, and decarboxylation products. The latter compounds are also obtained after oxidation of the same substrates by the SO4?? radical anion. Evidence was provided for the protecting effects afforded by cinnamic acid and hydroxylated derivatives against oxidative reaction mediated by HO?. By using adenine as a model compound, the results obtained suggest that the high protective effect is due to an antioxidising cascade process. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | cinnamic acid derivatives oxidative stress antioxidant effect free radicals |
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