Modification of polyethersulfone membranes using terpolymers engineered and integrated antifouling and anticoagulant properties |
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| Authors: | Chao He Chuan‐Xiong Nie Wei‐Feng Zhao Lang Ma Tao Xiang Chong Cheng Shu‐Dong Sun Chang‐Sheng Zhao |
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| Institution: | College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, , Chengdu, 610065 China |
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| Abstract: | In this study, random terpolymers of methoxy poly(ethylene glycol)‐poly(sodium styrene sulfonate‐co‐methyl methacrylate) (MPEG‐P(SSNa‐co‐MMA)) integrated with antifouling and anticoagulant properties were synthesized by atom transfer radical polymerization (ATRP) for the first time and confirmed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and gel permeation chromatography (GPC). The terpolymers with desired antifouling and anticoagulant segments were then used as amphiphilic additives to modify polyethersulfone membranes by an engineering blended approach. Water contact angle (WCA) results indicated that the surface hydrophilicity of the modified membranes enhanced. Protein ultrafiltration experiments showed that the antifouling ability of the modified membranes increased. In addition, the modified membranes showed decreased protein adsorption (bovine serum albumin, BSA), suppressed platelet adhesion, and prolonged activated partial thromboplastin time (APTT). Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | ATRP terpolymer antifouling ability anticoagulant property polyethersulfone membrane |
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