Sequential interpenetrating poly(ethylene glycol) hydrogels prepared by UV‐initiated thiol–ene coupling chemistry |
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Authors: | Ting Yang Michael Malkoch Anders Hult |
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Institution: | Department of Fiber and Polymer Technology, KTH Royal Institute of Technology, School of Chemical Science and Engineering, SE 100 44 Stockholm, Sweden |
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Abstract: | Poly(ethylene glycol) (PEG)‐diallyls, ranging from 2 to 8 kDa, were successfully reacted with a trifunctional thiol crosslinker via thiol–ene coupling reaction to construct four different primary PEG hydrogels. These systems were used as scaffolds for the preparation of a library of sequential interpenetrating networks (SeqIPNs). The solid content of the secondary networks varied between 21 and 34% and was dependent on the length of the absorbing PEGs. The gel fractions for the IPNs were above 85%. Additionally, the lowest degree of swelling was found for the IPN based on 2‐kDa PEG (315%), whereas the 8‐kDa PEG IPN exhibited a value of 810%. The SeqIPN strategy facilitated hydrogel systems that cover a larger domain of tensile modulus (192–889 kPa) when compared with single hydrogel networks (175–555 kPa). © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013 |
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Keywords: | hydrogels interpenetrating networks (IPN) mechanical property modulus networks polyethers poly(ethylene glycol) swelling degree thiol– ene click chemistry UV curing |
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